My Brother the Shut-In Vol. 6 (Kodansha, 2018)

Despite the ups and downs of Shino's youth, she charges ahead toward her dream of becoming a professional hair and makeup artist. She thinks about what she should do to follow her own path, and the decision she reaches is.... As if trying to take back the time he'd lost while shut in his room, Tamotsu had been falling in and out of love until finally, he meets the woman of his destiny(?)... He run into an insurmountable hurdle, but nevertheless finds happiness...no, misery.... The tale of the siblings' growth finally reaches its climax!